GD真人jinri，guojiganzangbingxuelingyudedingjiqikan《journal of hepatology》yi“dicoumarol, an nqo1 inhibitor, blocks cccdna transcription by promoting degradation of hbx”weitimu，zaixianfabiaolezhongqingyikedaxueganranbingjiaoyubuzhongdianshiyanshihuangailongjiaoshoutuanduidezuixinyixingganyanbingduyanjiuchengguo。gailunwenzhong，chengshengtaoboshizuoweidiyizuozhe，huangailongjiaoshouhechenjuanjiaoshouzuoweigongtongtongxunzuozhe，shizhongqingyikedaxueganranxingjibingfenzishengwuxuejiaoyubuzhongdianshiyanshijinqifabudeyouyilizuo。
GD真人yiganbingdugongjiabihehuanzhuang dna(cccdna)shibingdujinruxibaohoushouxianxingchengdechanwu，zaiganxibaoheneikexingchengweixiaoranseti。cccdnazuoweihbvfuzhidezhongxin，duiyiganbingdudefuzhihechixuganranzhuangtaidejianlijuyoushifenzhongyaodeyiyi。hbv cccdnazaiganxibaoheneichixuwendingdecunzai,beirenweishihbvganranmanxinghua、kangbingduzhiliaowufachediqingchuyijitingyaohouganyanfufadezuizhuyaoyuanyin。yinci，hbv cccdnachixuchenmoshimanxingyixingganyan“gongnengxingzhiyu”demubiao。bingdudanbaihbxduihbv cccdnadezhuanluguochengfahuiguanjianzuoyong; yizhihbxgongneng，zekenengyizhicccdnazhuanlu。yinci， hbxdanbaishikangbingduyaowuyanfadeyigezhongyaobadian。
gaixianggongzuoyibingdudanbaihbxweibabiao，tongguohibit-tagged hbx danbaijiancexitong，xunzhaodaoyigebaxiangzuoyongyuhbxdexiaofenzihuahewu:
shuangxiangdousu。zaihbvganranxibaomoxingherenyuanhuaganzangxiaoshumoxingzhong，shuangxiangdousujunkexianzhucujinhbxdanbaijiangjie，jinerxianzhuyizhihbv cccdnadezhuanlu。jinyibujizhijiexifaxianshuangxiangdousukezuoweixibaonqo1yizhiji，jiechunqo1duihbxdanbaidebaohuzuoyong，congercujinhbxdanbaijingfansufeiyilaide-20sdanbaimeititujingdejiangjie。
gaixianggongzuoshoucijieshisuzhuyinzinqo1zaidiaojiehbxdanbaizhiwendingxinghecccdnazhuanlufuzhizhongdezhongyaogongneng；baxiangbingdudanbaihbxdexiaofenzihuahewudeshaixuanjiangyouzhuyuxinxingkangbingduyaowudekaifa。
jinnianlai，huangailongjiaoshoutuanduiweiraoyixingganyanbingdugdzhenrenledaliangyanjiugongzuo，qudeleyixiliezhongyaochengguo，xianhouduocifabiaozaiguojiganzangbingxuelingyudedingjiqikan《hepatology》he《journal of hepatology》。(《journal of hepatology》，zhongkeyuanjcrfenqu1qu，yingxiangyinzi20.582)。
GD真人gaiyanjiuchengguoshoudaoguojiazirankexuejijinguojihezuoxiangmu（xiangmubianhao:
81861168035）、guojiazirankexuejijinmianshangxiangmu（xiangmubianhao:
81922011he81871656），yijiguojiazhongdakejizhuanxiang、zhongqingshigaoxiaochuangxinquntihezhongqingshikeweixiangmudengzizhu。
