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xuexiaochuangjianyu1956nian,youshanghaidiyiyixueyuan(xianfudandaxueshanghaiyixueyuan)fenqianlaiyuzujian,yuanmingzhongqingyixueyuan,1985niangengmingweizhongqingyikedaxue。

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黄爱龙教授团队在《Journal of Hepatology》发文发现新型抗乙肝病毒的小分子化合物

发布时间: 2020-10-14来源:GD真人 | 官网 阅读量: []

GD真人jinri,guojiganzangbingxuelingyudedingjiqikan《journal of hepatology》yi“dicoumarol, an nqo1 inhibitor, blocks cccdna transcription by promoting degradation of hbx”weitimu,zaixianfabiaolezhongqingyikedaxueganranbingjiaoyubuzhongdianshiyanshihuangailongjiaoshoutuanduidezuixinyixingganyanbingduyanjiuchengguo。gailunwenzhong,chengshengtaoboshizuoweidiyizuozhe,huangailongjiaoshouhechenjuanjiaoshouzuoweigongtongtongxunzuozhe,shizhongqingyikedaxueganranxingjibingfenzishengwuxuejiaoyubuzhongdianshiyanshijinqifabudeyouyilizuo。

GD真人yiganbingdugongjiabihehuanzhuang dna(cccdna)shibingdujinruxibaohoushouxianxingchengdechanwu,zaiganxibaoheneikexingchengweixiaoranseti。cccdnazuoweihbvfuzhidezhongxin,duiyiganbingdudefuzhihechixuganranzhuangtaidejianlijuyoushifenzhongyaodeyiyi。hbv cccdnazaiganxibaoheneichixuwendingdecunzai,beirenweishihbvganranmanxinghua、kangbingduzhiliaowufachediqingchuyijitingyaohouganyanfufadezuizhuyaoyuanyin。yinci,hbv cccdnachixuchenmoshimanxingyixingganyan“gongnengxingzhiyu”demubiao。bingdudanbaihbxduihbv cccdnadezhuanluguochengfahuiguanjianzuoyong; yizhihbxgongneng,zekenengyizhicccdnazhuanlu。yinci, hbxdanbaishikangbingduyaowuyanfadeyigezhongyaobadian。

gaixianggongzuoyibingdudanbaihbxweibabiao,tongguohibit-tagged hbx danbaijiancexitong,xunzhaodaoyigebaxiangzuoyongyuhbxdexiaofenzihuahewu: shuangxiangdousu。zaihbvganranxibaomoxingherenyuanhuaganzangxiaoshumoxingzhong,shuangxiangdousujunkexianzhucujinhbxdanbaijiangjie,jinerxianzhuyizhihbv cccdnadezhuanlu。jinyibujizhijiexifaxianshuangxiangdousukezuoweixibaonqo1yizhiji,jiechunqo1duihbxdanbaidebaohuzuoyong,congercujinhbxdanbaijingfansufeiyilaide-20sdanbaimeititujingdejiangjie。

gaixianggongzuoshoucijieshisuzhuyinzinqo1zaidiaojiehbxdanbaizhiwendingxinghecccdnazhuanlufuzhizhongdezhongyaogongneng;baxiangbingdudanbaihbxdexiaofenzihuahewudeshaixuanjiangyouzhuyuxinxingkangbingduyaowudekaifa。

jinnianlai,huangailongjiaoshoutuanduiweiraoyixingganyanbingdugdzhenrenledaliangyanjiugongzuo,qudeleyixiliezhongyaochengguo,xianhouduocifabiaozaiguojiganzangbingxuelingyudedingjiqikan《hepatology》he《journal of hepatology》。(《journal of hepatology》,zhongkeyuanjcrfenqu1qu,yingxiangyinzi20.582)。

GD真人gaiyanjiuchengguoshoudaoguojiazirankexuejijinguojihezuoxiangmu(xiangmubianhao: 81861168035)、guojiazirankexuejijinmianshangxiangmu(xiangmubianhao: 81922011he81871656),yijiguojiazhongdakejizhuanxiang、zhongqingshigaoxiaochuangxinquntihezhongqingshikeweixiangmudengzizhu。

(编辑: 蔡雨齐)
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